take up with . take up with {v.} To begin to go around with (someone); see a lot of. Frank has taken up with Lucy lately. Categories: add yours add yours {v.} Source: A Dictionary of American Idioms by A. Makkai, M.T. Boatner, J.E. Gates © 2025 To section: T Subscribe to: American Idioms► Also consider the parent subscriptions (3)Idioms feedEnglish languageHome page and general feed Discuss Discuss